Meperidine
Demerol
Class:
Opioid Analgesic
Opioid Analgesic
Mechanism of Action:
Synthetic opiod agonist that acts on opioid receptors to produce analgesia, euphoria, respiratory and physical depression.
A schedule II drug with potential for physical dependance and abuse.
Synthetic opiod agonist that acts on opioid receptors to produce analgesia, euphoria, respiratory and physical depression.
A schedule II drug with potential for physical dependance and abuse.
Indications:
Analgesia for moderate to severe pain.
Analgesia for moderate to severe pain.
Contraindications:
- Hypersensitivity to narcotic agents.
- Diarrhea caused by poisoning.
- Patients taking MAOIs.
- During labor or delivery of a premature infant.
- Undiagnosed abdominal pain or head injury.
Adverse reactions:
Respiratory depression, sedation, apnea, circulatory depression, dysrhythmias, shock, euphoria, delirium, agitation, hallucinations, visual disturbances, coma.
Seizures, headache, facial flushing.
Increased ICP, nausea, vomiting.
Respiratory depression, sedation, apnea, circulatory depression, dysrhythmias, shock, euphoria, delirium, agitation, hallucinations, visual disturbances, coma.
Seizures, headache, facial flushing.
Increased ICP, nausea, vomiting.
Drug Interactions:
- Do not give concurrently with MAOIs (even with a dose in the last 14 days!).
- Exacerbates CNS depression when given with these medications.
Adult Dosage and Administration
- IM / SC: 50-100 mg.
- IV: 25-50 mg slowly.
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Pediatric Dosage and Administration:1-2 mg/kg / dose IV, IO, IM, SC.
Duration of Action:
- Onset: IM: 10-45 minutes; IV: immediate.
- Peak effect: 30-60 minutes.
- Duration: 2-4 hours.