Drug Cards

Ketorolac

Toradol
Class:
Nonsteroidal anti inflammatory (NSAID)
Mechanism of Action:
Ketorolac is an anti-inflammatory drug that also exhibits peripherally acting non-narcotic analgesic activity by inhibiting prostaglandin synthesis.
Indications:
Short-term management (less than 5 days) of moderate to severe pain.
Contraindications:
  • Hypersensitivity to the drug.
  • Allergies to aspirin or other NSAIDs.
  • Bleeding disorders.
  • Renal failure.
  • Active peptic ulcer disease.
Adverse reactions:
  • Anaphylaxis from hypersensitivity.
  • Edema.
  • Sedation.
  • Bleeding disorders.
  • Rash.
  • Nausea.
  • Headache.
Drug Interactions:
  • Ketorolac may increase bleeding time when administered to patients taking anticoagulants.
  • Effects of lithium and methotrexate may be increased.
Adult Dosage and Administration
  • IM: 1 dose of 60 mg (for patients <65 years of age); 1 dose of 30 mg for patients >65 years of age, have renal impairment and or weigh less than 50 kg.
  • IV: 30 mg over 1 min (for patients <65 years of age or weigh less than 50 kg); one-half dose (15mg) for patients >65 years of age, have renal impairment, and/or weigh less than 50 kg.
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Pediatric Dosage and Administration:
Not recommended.
Duration of Action:
  • Onset: Within 10 minutes.
  • Duration: 6-8 hours.
Special Considerations:
  • Pregnancy safety: Category C.
  • Solution is clear and slightly yellow.
  • Use with caution and reduce dose when administering to elderly patients.