Drug Cards

Etomidate

Amidate
Class:
Nonbarbituate hypnotic, anesthesia induction agent.
Mechanism of Action:
Short acting hypnotic that acts at the level of the reticular activating system.
Indications:
Premedication for RSI.
Contraindications:
  • Hypersensitivity.
  • Labor/delivery.
  • Septic shock.
Adverse reactions:
  • Apnea of short duration.
  • Respiratory depression.
  • Hypoventilation.
  • Hypotension.
  • Dysrhythmias.
  • Nausea.
  • Vomiting.
  • Involuntary muscle movement.
Drug Interactions:
Effects may be enhanced when given with other CNS depressants.
Adult Dosage and Administration
0.2-0.6 mg/kg IV (typical adult dose is 20mg)
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Pediatric Dosage and Administration:
0.2-0.5 mg/kg IV/IO to assist with RSI (over 10 years old), one time only, max 20 mg.
Duration of Action:
  • Onset: Less than 1 minute.
  • Peak effect: 1 minute.
  • Duration: 5-10 minutes.
Special Considerations:
  • Pregnancy safety: Category C.
  • Use caution weighing fetal risk and maternal benefit in pregnant and breastfeeding women.