Aspirin
Acetylsalicylic acid (ACA)
Class:
Platelet inhibitor, anti-inflammatory agent.
Transient vasodilator in ACS
Platelet inhibitor, anti-inflammatory agent.
Transient vasodilator in ACS
Mechanism of Action:
Prostaglandin inhibition (makes platelets less sticky). Blocks Thromboxane A2 via COX 1 pathway. Vasodilation of coronary arteries via the COX 2 pathway.
Prostaglandin inhibition (makes platelets less sticky). Blocks Thromboxane A2 via COX 1 pathway. Vasodilation of coronary arteries via the COX 2 pathway.
Indications:
Chest pain suggestive of Acute Myocardial Infarction.
Chest pain suggestive of Acute Myocardial Infarction.
Contraindications:
- Hypersensitivity.
- Gastrointestinal bleeding.
- Signs and symptoms suggestive of recent cerebrovascular accident.
Adverse reactions:
Heartburn. GI bleeding. Nausea, vomiting. Wheezing in allergic patients. Prolonged bleeding.
Heartburn. GI bleeding. Nausea, vomiting. Wheezing in allergic patients. Prolonged bleeding.
Drug Interactions:
Use with caution in patients allergic to NSAIDs.
Use with caution in patients allergic to NSAIDs.
Adult Dosage and Administration
162 mg to 324 mg PO.
162 mg to 324 mg PO.
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Pediatric Dosage and Administration:Not recommended.
Duration of action:
- Onset: 30-45 minutes.
- Peak effect: variable.
- Duration: variable.
Special Considerations:
Pregnancy Safety: Category D.
Not recommended in pediatric populations.
Pregnancy Safety: Category D.
Not recommended in pediatric populations.