Amiodarone
Cordarone
Class:
Antidysrhythmic.
Antidysrhythmic.
Mechanism of Action:
Class III Potassium channel blocker. Prolongation of Action Potential; non-competitive alpha and beta sympathetic blocking effects; Calcium and Sodium channel blocking effects.
Class III Potassium channel blocker. Prolongation of Action Potential; non-competitive alpha and beta sympathetic blocking effects; Calcium and Sodium channel blocking effects.
Indications:
- Suppression of Ventricular Fibrillation / Pulseless Ventricular Tachycardia refractory to defibrillation
- Suppression of Ventricular Tachycardia with a pulse
Contraindications:
- Allergy to Iodine.
- Medication-induced Ventricular dysrhythmias.
- Torsades de Pointes.
Adverse reactions:
Hypotension, Bradycardia, Pulseless Electrical Activity, Congested Heart Failure, Nausea, Fever.
Hypotension, Bradycardia, Pulseless Electrical Activity, Congested Heart Failure, Nausea, Fever.
Drug Interactions:
Will precipitate with Sodium Bicarbonate: incompatible.
Will precipitate with Sodium Bicarbonate: incompatible.
Adult Dosage and Administration
- VF / Pulseless VT:
300 mg IV Push, can be diluted in 14 ml Normal Saline
Repeat Dose:
150mg can be diluted in 7ml Normal Saline - V Tac with a Pulse:
150 mg in 100mL NS infused over 10 minutes - Infusion:
1mg / min Mix 100 mg (2ml) in 100 ml of NS. COH 1mg'ml
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Pediatric Dosage and Administration:- VF / Pulseless VT:
5mg/kg slow IV Push over 1-2 minutes in 10 ml Normal Saline
Duration of Action:
- Onset: Within 5-15 minutes.
- Peak Effect: Variable.
- Duration: Variable.
Special Considerations:
Pregnancy Safety: Category C
Admnister cautiously in patients with Heart Failure or poor systolic function.
Pregnancy Safety: Category C
Admnister cautiously in patients with Heart Failure or poor systolic function.