Tranexamic Acid
TXA, Cyclokapron
Class:
Hemostatic agent, Antifibrinolytic, Plasminogen inactivator.
Hemostatic agent, Antifibrinolytic, Plasminogen inactivator.
Mechanism of Action:
Reduces plasminogen activation, mitigating conversion to plasmin.
Reduces plasminogen activation, mitigating conversion to plasmin.
Indications:
Blunt or penetrating trauma less than 3 hours from MOI*, with hemodynamic compromise, bleeding.
Blunt or penetrating trauma less than 3 hours from MOI*, with hemodynamic compromise, bleeding.
Contraindications:
- Hypersensitivity.
- Subarachnoid hemorrhage.
- History of PE**.
- DVT***, or other thromboembolitic event.
- MOI* greater than 3 hours.
Adverse reactions:
Fatigue, headache, abdominal pain, anemia, DVT, PE, other thromboembolic disorder. Rapid infusion may cause hypotension.
Fatigue, headache, abdominal pain, anemia, DVT, PE, other thromboembolic disorder. Rapid infusion may cause hypotension.
Adult Dosage and Administration
1000 mg in 100 mL of NS infused over 10 minutes.
1000 mg in 100 mL of NS infused over 10 minutes.
🧸
Pediatric Dosage and Administration:Not recommended.
Duration of Action
- Onset: Unknown
- Peak effect: Unknown
- Duration: 7-8 hours
Special Considerations:
* Mechanism of Injury.- Pregnancy Safety: Category C
- Use in pregnant and breastfeeding women should be clearly indicated.
- Must be mixed into an infusion bag, typically 100 mL of NS.
** Pulmonary Embolism.
*** Deep Vein Thrombosis.