Midazolam
Versed
Class:
Short-acting benzodiazepine CNS depressant.
Short-acting benzodiazepine CNS depressant.
Mechanism of Action:
- Increased production of GABA, an inhibitory neurotransmitter, causing procedural amnesia; anesthesia; skeletal muscle relaxation.
- Anxiolytic and sedative / hypnotic properties similar to other benzodiazepines.
Indications:
- Status Seizure.
- Sedation
- Anxiolysis prior to oral or nasal intubation
- Synchronized cardioversion.
Contraindications:
- Glaucoma.
- Shock.
- Coma.
- Alcohol intoxication.
- Overdose patient.
- Depressed vital signs.
- Concomitant use with other CNS depressants, barbituates, alcohol, narcotics.
Adverse reactions:
Hypotension, respiratory depression and arrest.
Hiccouch, cough, over-sedation, nausea, vomiting, injection site pain, headache, blurred vision.
Hypotension, respiratory depression and arrest.
Hiccouch, cough, over-sedation, nausea, vomiting, injection site pain, headache, blurred vision.
Adult Dosage and Administration
- Seizures: 2-6 mg slow IV/IO/IM (may be repeated to total maximum: 0.1 mg/kg), 10mg IN
- Cardioversion / Sedation: 0.5 - 2 mg IV/IO/IM/IN max 0.1 mg/kg
- Intubation / Difficult Airway: 0.05 mg/kg IV/IO max 5mg. Repeat in 5-10 at half original dose x 2. Max 10 mg
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Pediatric Dosage and Administration:- Seizures: 0.1 mg/kg IV/IO/IM Max 8mg or 0.2 mg/kg IN Max 10 mg
- Cardioversion / Sedation: 0.05 - 0.1 mg/kg IV
- Intubation / Difficult Airway: To facilitate intubation: Medical control may order:
- 6 months - 5 years: 0.05-0.1 mg/kg IV maximum dose of 5 mg.
- 6 - 12 years old: 0.1 mg/kg IV maximum dose of 8 mg.
Special Considerations:
- Pregnancy safety: Category D.
- Administer immediately prior to intubation procedure.
- Requires continuous monitoring of respiratory and cardiac function.